ASSOCIATION OF VICTIMS OF MEDICINES
Immunology - toxicology
According to our information, it is possible to verify the causal relationship between taking a drug and occurence of Stevens Johnson syndrome or toxic epidermal necrolysis in a victim, by a lymphocyte transformation test. Also according to our records if the result is positive: it is reliable and if the result is negative: the responsibility of the drug is not excluded.
The Laboratory of Immunology which we use, also uses the basophil activation test to verify the causal relationship between taking a drug and the occurrence of Stevens Johnson syndrome or toxic epidermal necrolysis for a victim. Lymphocyte transformation test and basophil activation test are made in the laboratory of immunology, but all immunology laboratories may not have the competence to do so.
According to an article published in the journal prescrire (French independent medical review of the pharmaceutical industry), if the stevens johnson syndrome may have a viral, bacterial or drug causal factor; all lyell syndrome (toxic epidermal necrolysis) are due to drugs.Prescrire article of May 2008 number 295 page 347 "Lyell's syndrome (toxic epidermal necrolysis) is exclusively due to drugs. For stevens johnson syndrome different origins are viral and bacterial infections or drugs. Stop the drugs in question as soon as possible improves the vital prognosis. "
Also according to our information, a new technique is being studied to determine the causal relationship between taking a drug and the occurence of Stevens Johnson syndrome or toxic epidermal necrolysis for a victim: toxicogenomics. The results are promising, but still confidential. Here is a link to an association of researchers in toxicology, which is campaigning for toxicogenomics.
Avimedi is an association providing information about Stevens Johnson syndrome and Lyell syndrome, anti-inflammatory medicines and anti-epileptics after-effects and other Stevens Johnson syndrome causal factors.